Health research

NT Health clinical trials register

If you have any queries in regards to any of the above clinical trials, please contact NT Health Research Governance Office (RGO) on 08 8922 7561 or nthealth.rgo@nt.gov.au

Study short tile / acronym Health condition Study full title Site principal investigator Link to ANZCTR / Clinicaltrials.gov
ACT-2Type 2 Myocardial Infarction (MI) , Myocardial injuryType 2 Myocardial Infarction (MI) , Myocardial injuryDr Hussam Tayebhttps://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374157&isReview=true

AMLM22 (IAPC)

Acute myeloid leukaemia (AML)

The International AML Platform Consortium (IAPC) Trial

Dr Emma Palfreyman

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12619000248167

ARiSE Fluids

Septic Shock

Australian Resuscitation in Sepsis Evaluation: Fluid or vasopressors in Emergency Department Sepsis

Dr Sandra Brownlea

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=19156&isClinicalTrial=True

ARROW

Recurrent Wheeze/ Respiratory

ARROW – Assessing the Reduction of Recurrent admissions with OM-85 for preschool Wheeze

Dr Kathryn Roberts

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380570&isReview=true

ASCOT

COVID-19 (SARS-CoV-2)

Australasian COVID-19 Trial (ASCOT): A multi-centre randomised clinical trial to assess clinical, virological and immunological outcomes in patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care.

Dr Jane Davies

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379542&isReview=true

ASCOLT

Colorectal Cancer

ASCOLT: Aspirin for Dukes C and High Risk Dukes B Colorectal Cancer. An International, Multi centre, Double Blind, Randomised, Placebo Controlled Phase III Trial.

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365996&isReview=true

ASPIRING

Intracerebral Hemorrhage

Antiplatelet Secondary Prevention International Randomised trial after INtracerebral haemorrhage (ASPIRING)

Dr Alvaro Cervera

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=19590&isClinicalTrial=True

BALANCE

Urinary Tract Infection / Urinary Sepsis / Bacteraemia

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): Randomized Controlled Trial

Dr Catherine Marshall

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380457&isReview=true

BONANZA

Severe Traumatic Brain Injury

Brain Oxygen Neuromonitoring in Australia and New Zealand Assessment

A/Prof Lewis Campbell

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378178&isReview=true

BREATH

Bronchiectasis / Respiratory

The BREATH Study: short and long-term effects of therapeutic exercise in children with bronchiectasis: a multi-centre randomised controlled trial

Kim Clayworth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377843&isReview=true

CAPTURE

Advanced Breast Cancer

CAPTURE: A phase II randomised study to evaluate alpelisib plus fulvestrant versus capecitabine in oestrogen receptor-positive, HER2-negative advanced breast cancer patients with PIK3CA mutant circulating DNA

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377949&isReview=true

CARBUNCLE

Surgical Treatment of Carbuncle

Carbuncle RCT: Limited Excision versus Saucerisation

Dr Richard Bradbury

 

D-KIDS

Acute Respiratory Infection

D-Kids: Vitamin D supplementation to prevent respiratory infections among Indigenous children in the Northern Territory: a randomised controlled trial

Prof Peter Morris

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375278&isReview=true

DYNAMIC III

Colorectal Cancer

Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage III Colon Cancer: A Multicentre Phase II/III Randomised Controlled Study

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617001566325

EASY AS

Aortic Stenosis  / Cardiovascular

The Early valve replacement in severe ASYmptomatic Aortic Stenosis (EASY AS) trial

Dr Hussam Tayeb

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=19243&isClinicalTrial=True

ENZAMET

Prostate Cancer

Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=4975&isClinicalTrial=True

FRAIL-M

Multiple Myeloma

Frailty-stratified, randomised controlled Bayesian adaptive trial of bortezomib versus lenalidomide in transplant-ineligible myeloma (FRAIL-M)

Dr Ferenc Szabo

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12619001199101

Hearing for Learning

Otitis Media / Conductive Hearing Loss

The Hearing for Learning Initiative - an innovative community-based service-enhancement model to address the crisis in ear and hearing health of Aboriginal children in the Northern Territory: a Phase III stepped-wedge cluster randomised controlled trial

Prof Amanda Leach

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=18174&isClinicalTrial=True

HomeBase2

Chronic Obstructive Pulmonary Disease / Respiratory

HomeBase2: An implementation trial to improve access to pulmonary rehabilitation in people with chronic obstructive pulmonary disease

Coralie Branelly

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=18662&isClinicalTrial=True

INFERR

Anaemia / Liver Disease / Kidney Disease

Iron infusion in Haemodialysis Study: Intravenous Iron Polymaltose For Indigenous Patients with High Ferritin Levels on Haemodialysis: A Prospective Open-Label Blinded Endpoint Randomised Controlled Trial

A/Prof William Majoni

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378517&isReview=true

INTEGRATE IIb

Advanced Gastro-Oesophageal Cancer (AGOC)

Randomised Phase III Controlled Trials of Regorafenib containing regimens versus standard care in Refractory Advanced Gastro-Oesophageal Cancer (AGOC)

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370302&isReview=true

MEGA-ROX

Critical Illness / Emergency Medicine

The Mega Randomised Registry Trial Comparing Conservative vs. Liberal OXygenation Targets

A/Prof Lewis Campbell

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379432&isReview=true

MoST Framework - Screening

Molecular Screening / Cancer

The Cancer Molecular Screening and Therapeutics (MoST) Program – A framework protocol for multiple, parallel, signal-seeking clinical studies of novel molecularly targeted therapies for patients with advanced cancer and unmet clinical need

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370660&isReview=true

MoST 4 (substudy 9)

Cancer / PTCH1 or SMO mutations

Single arm, open label, signal seeking, phase IIa trial of the activity of vismodegib in patients with tumours harbouring PTCH1 or SMO mutations

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374370&isReview=true

MoST 6 (substudies 14-15)

Cancer / NTRK1-3 positive tumours.

Single arm, open label, signal seeking, phase IIa trial of the activity of larotrectinib in patients with advanced NTRK1-3 positive tumours.

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377225&isReview=true

MoST 7 (substudies 16-18)

Advanced rare or neglected cancers

Single arm, open label, signal seeking, phase II trial of Tremelimumab in patients with tumours with advanced rare or neglected cancers

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378934&isReview=true

MoST 8 (substudies 19-20 & 35-36)

Cancer / HER2 amplifications or mutations

Single arm, open label, signal seeking, phase IIa trial of the activity of Trastuzumab emtansine (T-DM1) in patients with tumours harbouring HER2 amplifications or mutations

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378088&isReview=true

MoST 9 (substudies 21-22)

Cancer / HER2 amplifications or mutations

Single arm, open label, signal seeking, phase II trial of the activity of tucatinib plus trastuzumab in patients with tumours harbouring HER2 amplifications or mutations

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379978&isReview=true

MoST 10 (substudies 23-24)

Cancer / amplified D-type cyclins or CDK4/6 or inactivation of CDKN2A.

Single arm, open label, signal seeking, phase II trial of the activity of Palbociclib in combination with Avelumab in patients with tumours with amplified D-type cyclins or CDK4/6 or inactivation of CDKN2A.

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379754&isReview=true

MoST 12 (substudies 27-30)

Lung Cancer / Other tumours harbouring BRAF V600 mutations

Single arm, open label, phase II trial of vemurafenib and cobimetinib in patients with advanced tumours harbouring BRAF V600 mutations detected by comprehensive genomic profiling

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379986&isReview=true

MoST 13 (substudy 31)

Cancer / NTRK fusions or ROS1 gene

A single-arm, open-label, phase II trial of entrectinib in patients with advanced tumours harbouring NTRK fusions or ROS1 gene rearrangements detected by comprehensive genomic profiling

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381225&isReview=true

MoST 14 (substudy 32)

ALK gene alterations

Non-small cell lung cancer

A Single arm, open label, phase II trial of alectinib in patients with advanced tumours harbouring ALK gene alterations detected by comprehensive genomic profiling

Dr Michail Charakidis

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381213&isReview=true

My Baby's movements

Fetal complications of pregnancy

My Baby's Movements: a stepped wedge cluster randomised control trial to raise maternal awareness of fetal movements during pregnancy (My Baby's Movements Multi-Centre Trial)

Dr Sujatha Thomas

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=365867&isReview=true

NAVIGATE

Solid Tumors Harboring NTRK Fusion

A phase 2 Basket Study of the Oral TRK Inhibitor larotrectinib in subjects with NTRK Fusion – Positive Tumors

Dr Sabeeh Butt

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=18760&isClinicalTrial=True

ORVAC

Viral Gastroenteritis Due to Rotavirus

A phase IV, double blind, randomised, placebo controlled clinical trial of a third scheduled dose of RV1 rotavirus vaccine in Australian Indigenous infants to improve protection against gastroenteritis

Dr Bianca Middleton

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=7011&isClinicalTrial=True

PARROT

Neurological impairment / Lower respiratory tract infection

Prophylactic antibiotics to prevent recurrent lower respiratory tract infections in children with neurological impairment (PARROT) study

Prof Anne Chang

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378218&isReview=true

PETAL

Acute lower respiratory infection in children

Preventing recurrent Acute Lower Respiratory infections in young Indigenous Children (PETAL) study

Prof Peter Morris

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377132&isReview=true

PneuMatters

Acute Lower Respiratory Infection

Preventing early-onset pneumonia in high risk children through maternal immunisation: a multi-centre randomized controlled trial.

Dr David Simon/Prof Anne Chang

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374381&isReview=true

PREDICT-TBI

Traumatic Brain Injury

PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury: the value of Magnetic Resonance Imaging and Artificial Intelligence

A/Prof Lewis Campbell

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380619&isReview=true

PROMPT BOLUS

Paediatric Shock, Septic

Pragmatic Paediatric Trial of Balanced versus Normal Saline Fluid in Sepsis (PROMPT BOLUS)

Dr Anna Lithgow

https://clinicaltrials.gov/ct2/show/NCT04102371?term=NCT04102371&draw=2&rank=1

REMAP-CAP

Community-acquired Pneumonia, Influenza, COVID-19

Randomised, Embedded, Multifactorial, Adaptive Platform trial for Community Acquired Pneumonia

A/Prof Lewis Campbell

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=17743&isClinicalTrial=True

RENO

Rectal Cancer

A Longitudinal Cohort Study of ‘Watch and Wait’ in Complete Clinical Responders after Chemoradiotherapy for Localised Rectal Cancer

Dr Narayan Karanth

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376810&isReview=true

REPEAT

Primary ciliary dyskinesia

REPEAT Study: Improving outcomes of children and young adults with primary ciliary dyskinesia: a multi-centre, double blind, double-dummy, 2x2 partial factorial, randomised controlled trial

Prof Anne Chang

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377259&isReview=true

ROCKet

Chronic post-surgical pain

Reduction of Chronic Post-surgical Pain with Ketamine-ROCKet Trial - A multicentre double-blind parallel-group placebo controlled randomised trial of the effect of perioperative ketamine on the risk of development of chronic post-surgical pain

Dr Elystan Hughes

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373323&isReview=true

STARS

Breast Cancer

A randomised comparison of Anastrozole before and continued during adjuvant radiotherapy for breast cancer versus Anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. (STARS – Study of Anastrozole and Radiotherapy Sequencing)

Dr Scott Caruthers

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=83913&isReview=true

TEACH-PD CRCT

Kidney Disease

Targeted Education ApproaCH to Improve Peritoneal Dialysis Outcomes – Cluster Randomised Controlled Trial (TEACH-PD CRCT)

Dr Bidhun Paulose

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=18600&isClinicalTrial=True

TORPIDO 30/60

Complications of premature newborns/ resuscitation

Targeted Oxygenation in the Respiratory care of Premature Infants at Delivery: Effects on Outcome

Dr Dennis Bonney

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=367049&isReview=true

VALDAC

Acute Myeloid Leukemia

VALDAC: A phase 2 study of venetoclax in combination with low-dose cytarabine in relapsing acute myeloid leukaemia

Dr Emma Palfreyman

https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377157&isReview=true

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Last updated: 25 November 2022

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