Sepsis

Sepsis is the body’s overwhelming and life-threatening response to an infection that can lead to tissue damage, organ failure and death. Recent data has revealed that on average 90,000 Australians are diagnosed with sepsis each year, with more than 13,000 people losing their life.

Sepsis starts with an infection which may result after surgery, from a wound, an illness or condition such as a urinary tract infection.

Most cases of sepsis can start at home but can also develop in hospital.

Sepsis is an emergency that starts quickly and requires treatment fast. If you think you have sepsis, seek medical treatment immediately by calling Triple Zero (000), or visiting a clinic or hospital.

Signs and symptoms

The signs and symptoms for sepsis differ between adults and children.

Adults:

  • short wind/fast breathing
  • heart beating too fast
  • Feeling really hot/fever
  • skin colour has changed/rash/mottled skin
  • runny poo/diarrhoea
  • feeling really tired or confused
  • feeling sick in the stomach/vomiting
  • feeling really cold/chills
  • not much urine
  • feeling so sick you feel like you could die
  • severe pain or discomfort.

Children:

  • fast breathing or long pauses in breathing
  • floppy body
  • blotchy, blue or pale skin
  • a lot of pain or very restless
  • fit or seizure
  • drowsy, difficult to wake up, irritable or confused
  • cold skin
  • rash that doesn’t fade when pressed
  • nausea, vomiting, unable to eat, drink or breastfeed
  • pass less urine or have fewer wet nappies.

You know your body and your child best. If you are concerned you, your child or loved one is sicker than ever before, or the illness is getting worse, ask ‘could it be sepsis?’

Post sepsis syndrome

Post sepsis syndrome (PSS) is a condition that includes physical and/or psychological long-term effects that can occur from having sepsis. PSS affects up to 50% of sepsis survivors and is more likely after experiencing an admission in ICU or a long hospital stay for severe sepsis. PSS can affect people at any age; however, the elderly and those with chronic diseases are at higher risk.

Post sepsis syndrome can result in various physical, cognitive, psychological and emotional symptoms, which can impact your quality of life after sepsis and your ability to return to normal daily activities.

Common symptoms of post sepsis syndrome include:

  • Physical symptoms
    • extreme fatigue and weakness
    • disabling muscle and joint pain
    • difficulty moving or poor mobility
    • shortness of breath
    • trouble sleeping/insomnia
    • hair loss, skin issues like dryness or peeling
    • swelling in the limbs
    • difficulty swallowing
  • Cognitive symptoms
    • poor concentration and memory loss
    • slowed thinking and difficulty with decision-making
    • impaired mental functioning
    • clouded thinking
  • Psychological & emotional symptoms
    • depression, anxiety, and loss of self-esteem
    • flashbacks, vivid dreams, nightmares or hallucinations
    • panic attacks
    • mood swings
    • feeling frustrated and socially isolated

Sepsis can affect your whole body. It is normal to go through a period of recovery after sepsis.  Rehabilitation and discharge planning should start early during your hospital stay to ensure the right people are involved in your care during and after leaving hospital. This may include allied health services such as physiotherapy, follow up with specialist doctors and community health services tailored to your needs for recovery.

Consumer resources

Websites

CategoryResourceWebsite
Website What is sepsis? Sepsis Alliance
Website Life after sepsis Sepsis Australia
Website National Sepsis Program Australian Commission on Safety and Quality in Health Care
Nutrition Tips to help with eating after a critical illness The Association of UK Dietitians
Mental Health Support Beyond Blue Beyond Blue
Mental Health Support Black Dog Institute Black Dog Institute
Mental Health Support Medicare Mental Health Medicare Mental Health
Mental Health Support Mental Health Australia Mental Health Australia
Mental Health Support Health Direct Health Direct
Amputee Support Limbs 4 Life Limbs 4 Life
Amputee Support Amputee Support Groups Queensland Health
Home Help Government Funded Support at Home Australian Government Department of Health, Disability and Ageing

Documents

CategoryResourceWebsite
Document Life after sepsis: A guide for survivors, carers and bereaved families Sepsis Australia
Document Information for people with sepsis and their families Australian Commission on Safety and Quality in Health Care
Exercise/rehabilitation Breathing after a critical illness ICUsteps
Exercise/rehabilitation Guide to recovery ICUsteps

TypeResourceAuthor
Website Australia and NZ Sepsis Support Group Facebook page Australia and NZ Sepsis Support Group
Website Patients and family Sepsis Alliance
Website Is it sepsis? IsItSepsis Charity (NT)

Health Professional resources

The NT Health sepsis guidelines are intended to support the sepsis pathways and provide further guidance in:

  • Best practice and a consistent approach across all NT health services for early sepsis recognition and management.
  • Where sepsis is suspected, empower staff to escalate care to clinicians experienced in recognising and managing sepsis.
  • Engaging senior medical staff in sepsis recognition and management of patients.
  • Supporting the provision of education and information for patient and carers.

For acute care:

For primary health care:

The Remote Health Atlas and Primary Health Network sites have updated their sepsis guidelines to align with NT Health to ensure consistency of practice across the NT.

The goal of the sepsis clinical care standard is to ensure that a patient presenting with signs and symptoms of sepsis receives optimal care, from symptom onset through to discharge from hospital and survivorship care.

This includes timely recognition of sepsis, early and appropriate antimicrobial therapy and continuity of care from the acute setting through to discharge and survivorship (Australian Commission on Safety and Quality in Health Care (ACSQHC), 2022).

The sepsis clinical care standard is linked to the antimicrobial stewardship clinical care standard, for more information about clinical care standards go to the ACSQHC website.

A sepsis e-learning module, Sepsis Introduction, is available to all health professionals via MyLearning. This module helps clinicians to understand what sepsis is, its impact in the NT, how to identify and manage sepsis, and with the use of case studies, assists in applying the sepsis pathways into practice.

A sepsis e-learning module is available from the Remote Area Health Corps (RAHC) e-learning site. This is for all health professionals who want to learn more about sepsis. The e-module uses case studies to familiarise you with the NT Health sepsis pathways and tests your knowledge about sepsis recognition and management processes. To complete the learning module, go to the RAHC website.

Medcast have developed a national sepsis module, Sepsis in Primary Care , designed to equip GPs and other primary care clinicians with strategies to recognise, assess, and manage sepsis across diverse patient populations. Learning is case study based and includes maternal and child sepsis, and post sepsis syndrome.

Watch the sepsis pathophysiology video.

Septris 2.0

Septris 2.0 is a mobile-accessible, case-based, online game launched worldwide and developed for hospital-based medical and surgical, intensive care and emergency department physicians and nurses for treating Sepsis.

Read more about Septris 2.0

Septris2.0

Post sepsis syndrome resources

TypeResourceWebsite
DocumentSuspected sepsis in people aged 16 or over: recognition, assessment and early management (2025) NICE guideline
Document Epidemiology of Sepsis in Australian Public Hospitals (2020) ACSQHC
Journal The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) (2016)  JAMA Network
Journal Sepsis in the tropical Top End of Australia’s Northern Territory: disease burden and impact on Indigenous Australians (2011)  Medical Journal of Australia
Journal Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Sepsis Shock (2026) Society of Critical Care Medicine
Document Review of trigger tools to support the early identification of sepsis in healthcare settings (2021) ACSQHC
Journal Sepsis - Pathophysiology and Therapeutic Concepts (2021)  Frontiers
Document Diagnosis and management of sepsis in the older adult (2023) BMJ Publishing Group Ltd

Rosie’s Story (3:16)

Surgical site infection leads to sepsis.

Ann’s Story (3:57)

Cancer survivor – post port-a-cath insertion infection that leads to death.

Geoff’s Story (8:13)

Splinter leads to septic shock.

Fiona’s Story (1:47)

Bump on elbow leads to sepsis.

TypeResourceWebsite
Journal Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children (2020) PubMed
Website Sepsis in children BMJ Best Practice
Website Sepsis and Children Sepsis Alliance
Journal Sepsis prediction in hospitalized children: Model development and validation (2023) American Academy of Pediatrics
Journal Sepsis prediction in hospitalized children: Clinical decision support design and deployment (2023) American Academy of Pediatrics
DocumentSuspected sepsis in under 16s: recognition, diagnosis and early managementNICE guideline

Mia’s Story (3:18)

Pre-hospital symptoms, if you are worried get help/go to ED.

Beauden’s Story (13:11)

From scrape to knee to septic shock, includes survivorship care/follow up.

Sepsis and Children (13:28)

From infected cut to quadruple amputation – includes globally recognised leading expert on sepsis in children.

Australian Story – Mia’s Story (8:06)

Sunrise article – family shares Mia’s story of surviving sepsis.

TypeResourceAuthor
Journal Diagnosis of neonatal sepsis: The past, present and future (2021)  International Pediatric Research Foundation, Inc
Journal Diagnosis of neonatal sepsis: The role of inflammatory markers (2022)  Medical University of Graz
Journal Neonatal sepsis definitions from randomised clinical trials (2021)  European Society for Paediatric Research (ESPR)

Global Health – Newborn Care Series (5:51)

Shows baby with sepsis, how to evaluate and treat.

Neonatal Sepsis: Newborn Blood Infection (4:37)

Causes, symptoms and treatment by Dr Nanditha, Neonatologist at Kangaroo Care.

Isla’s Story (3:42)

Baby wakes up lethargic, emergency transfer to Perth Children’s Hospital, signs and symptoms.

TypeResourceWebsite
Website Pregnancy and childbirth Sepsis Alliance
Journal Azithromycin to prevent sepsis or death in women planning a vaginal birth (2023)  A-PLUS Trial Group
DocumentSuspected sepsis in pregnant or recently pregnant people: recognition, diagnosis and early management (2025)NICE guideline

Maile’s Story – Maternal Sepsis (7:32)

Mother develops sepsis after returning home post birth.

Kayleigh’s Story (6:39)

Mother develops sepsis at 7 months gestation leading to quadruple amputation.

Amanda’s Story (6:04)

Mother develops sepsis 6 weeks post a traumatic birth.

TypeResourceWebsite
Document Sepsis survivorship: A review of the impacts of surviving sepsis for Australian patients (2021) ACSQHC
Website Sepsis Hub ACSQHC
DocumentCoordination of care and post-sepsis support: model of care framework (2025)ACSQHC
Document Stopping Sepsis: A National Action Plan (2017) The George Institute for Global Health
Journal Hospital-related costs of sepsis around the world: A systematic review exploring the economic burden of sepsis (2022)  University Medical Center Groningen
Journal Immunopathophysiology of human sepsis (2022)  eBioMedicine
Journal Sepsis-induced immunosuppression: Mechanisms, diagnosis and current treatment options (2022)  Military Medical Research
Journal Nurses' knowledge and confidence in recognizing and managing patients with sepsis: A multi-site cross-sectional study (2022)  National University of Singapore
Journal Embracing complexity in sepsis (2023)  Springer Nature
Journal Deployment of machine learning algorithms to predict sepsis: Systematic review and application of the SALIENT clinical AI implementation framework (2023)  Journal of the American Medical Informatics Association
Journal Early restrictive or liberal fluid management for sepsis-induced hypotension (2023)  The New England Journal of Medicine
Journal Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis (2023)  MDPI
Document 2030 global agenda for sepsis: Making the next success story in global health Global Sepsis Alliance

Help to spread awareness about sepsis and World Sepsis Day in your workplace with free access to resources and fun activities.

Read more about World Sepsis Day Toolkit

The World Sepsis Congress keeps you up to date on world-wide issues and evidence-based practice relating to sepsis.

Contacts

For more information and assistance, contact Clinical Excellence and Patient Safety by emailing ceps.health@nt.gov.au.


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